AbstractBackground: Head and neck cancers (HNCs) are a diverse and challenging group of malignancies, often necessitating radiotherapy. Conventional two-dimensional radiotherapy (CRT) has been widely used, yet it lacks the precision required for optimal outcomes in anatomically complex areas. This study compares the efficacy and safety of intensity-modulated radiotherapy (IMRT) with CRT in HNC patients.
Materials and Methods: A total of ten HNC patients were randomized to receive either CRT or IMRT over one year. Tumor response, toxicity profiles, and quality of life (QoL) scores were assessed. Data analysis involved descriptive and non-parametric statistical methods to compare outcomes between the two groups.
Results: The IMRT group demonstrated an 80% complete response rate compared to 40% in the CRT group. IMRT patients reported significantly lower toxicity rates, with fewer occurrences of Grade 2-3 mucositis and xerostomia. QoL scores were also notably higher in the IMRT group, with improvements in swallowing, speech, and overall well-being.
Conclusion: IMRT shows significant advantages over CRT in tumor control, reduced toxicity, and QoL enhancement for HNC patients. These findings support IMRT as a preferred modality for HNC treatment.
