AbstractBackground and Objectives: Assess the efficacy of transrectal ultrasound in the identification of prostate cancer. This work aims to assess the utility of strain elastography in prostate cancer cases for the identification of lesions and guidance of further biopsies. This study aims to compare the sonoelastographic results with the data from biopsies by classifying the outcomes using grading techniques. The aim of this work is to establish a connection between histology and the outcomes of sonoelastographic and greyscale imaging.
Methods: Prospective investigation comprised thirty patients with elevated PSA levels and abnormal DRE results who were referred to a physician at the Department of Radiology, Sambhram Institute of Medical Sciences and investigation, Bangalore, Karnataka, India, between September 2017 and September 2018. All patients underwent a simultaneous transrectal ultrasound, real-time strain elastography, and a systematic 12-core biopsy. Additional targeted biopsies were then collected from trouble regions detected by the transrectal ultrasound and real-time strain elastography. The histopathological diagnosis was compared to the interpretations provided by each of these approaches.
Results: Transrectal ultrasonography was 78.57 percent sensitive, 81.25 percent specific, had a positive predictive value of 78.57 percent, and a negative predictive value of 81.2 percent for detecting prostate cancer. Elastography's sensitivity was 100%, specificity was 50%, positive predictive value was 63.64%, and negative predictive value was 100% when used to detect prostate cancer.
Conclusion: Sonoelastography is a potentially novel diagnostic strategy for the detection of prostate cancer, either when utilised independently or in combination with existing ultrasonography techniques. Elastography has a higher negative predictive value and sensitivity for ruling out prostatic malignancies than standard ultrasound, which both contribute to reducing the number of unnecessary biopsies.
